SIRT1 Antibody
Catalogue Number: ASC11135-ABG
ASC11135 Image
ASC11135 Image
ASC11135 Image
ASC11135 Image
Western blot analysis of SIRT1 in mouse liver tissue lysate with SIRT1 antibody at 1 µg/mL.
ASC11135 Image
Immunofluorescence of SIRT1 in rat lung tissue with SIRT1 antibody at 20 µg/mL.
ASC11135 Image
Immunofluorescence of SIRT1 in mouse liver tissue with SIRT1 antibody at 20 µg/mL.
| Manufacturer: | Abcepta |
| Shelf Life: | 12 months |
| Molecular Weight: | 81681 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Chicken |
| Clone: | |
| Isotype: | IgY |
| Immunogen: | |
| Application: | ELISA, IF, WB |
Description
Description: SIRT1 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically via lysine residue.
Additional Text
Gene Name
SIRT1
Gene ID
23411
Uniprot ID
Q96EB6
Molecular Weight
81681
Application Notes
SIRT1 antibody can be used for detection of SIRT1 by Western blot at 1 µg/mL. Antibody can also be used for immunoflourescence starting at 20 µg/mL. For immunofluorescence start at 20 µg/mL.
Accession Number
NP_036370
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Storage Note
SIRT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ASC11135 Datasheet
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