ECRG2 Antibody
Catalogue Number: ASC11386-ABG
ASC11386 Image
ASC11386 Image
ASC11386 Image
Western blot analysis of ECRG2 in human lung tissue lysate with ECRG2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
ASC11386 Image
Immunohistochemistry of ECRG2 in rat lung tissue with ECRG2 antibody at 5 µg/mL.
| Manufacturer: | Abcepta |
| Shelf Life: | 12 months |
| Molecular Weight: | 9232 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Chicken |
| Clone: | |
| Isotype: | IgY |
| Immunogen: | |
| Application: | ELISA, IHC-P, WB, IHC |
Description
Description: ECRG2 Antibody: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.
Additional Text
Accession Number
AAI09386
Molecular Weight
9232
Gene ID
84651
Gene Name
SPINK7
Uniprot ID
P58062
Application Notes
ECRG2 antibody can be used for detection of ECRG2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL.
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Storage Note
ECRG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ASC11386 Datasheet
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