Alexa Fluor® 647 Anti-Human IL-17A (4H1524) Antibody

Catalogue Number: ATB10000-ABG

Manufacturer:	Abcepta
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	Interleukin IL-17A, IL-17, Cytotoxic T lymphocyte-associated antigen 8 (CTLA-8)\|Interleukin IL-17A, IL-17, Cytotoxic T lymphocyte-associated antigen 8 (CTLA-8), IL-17A
Shipping Condition:	Blue Ice
Unit(s):	100 tests
Host name:	Mouse
Clone:	4H1524
Isotype:	IgG2b, kappa
Immunogen:
Application:	FC

Overview
Datasheets

Description

Description: The 4H1524 antibody reacts with human Interleukin-17A (IL-17A), a member of the IL-17 cytokine family which includes IL-17A, IL-17B, IL-17C, IL-17E and IL-17F. These proteins share varying degrees of sequence homology and patterns of expression, and their unique functional roles are still being elucidated. IL-17A, originally known as CTLA-8 in mouse, can exist as homodimers and has also been shown to combine with IL-17F into an IL-17AF heterodimer, although the function of this form is not yet established. IL-17 expression originally led to recognition of the Th17 subset of CD4+ T cells, which is distinct from the Th1 / Th2 subsets previously described. The Th17 cell secretes a signature group of cytokines, including IL-17, IL-21 and IL-22, which support innate immune function within tissues at external barrier sites and are protective against external pathogens. IL-17A is an important mediator of inflammation and has been implicated in a variety of autoimmune processes. Among its many effector functions, IL-17A enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts and promotes expression of numerous cytokines by non-immune cells such as epithelial, endothelial, fibroblast and stromal cells. The 4H1524 antibody may be used for analysis of human IL-17A by intracellular staining in flow cytometry.

Additional Text

Gene Name

IL17A

Gene ID

3605

Application Notes

This antibody preparation has been pre-titrated and quality-tested for flow cytometry using an appropriate cell type. The antibody has been diluted for use at 5 uL per test, defined as the amount of antibody that will stain a cell sample in a final volume of approximately 100 uL. The number of cells within a sample should be determined empirically, but typically ranges between 1x10e5 to 1x10e8 cells.

Uniprot ID

Q16552

Antibody Clonality

Monoclonal

Storage Note

2-8°C protected from light

ATB10000 Datasheet

Price

£190.00

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