Biotin Anti-Mouse CD11c (N418) Antibody
Catalogue Number: ATB10076-ABG
| Manufacturer: | Abcepta |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | p150, integrin _X, Itgax, CR4, CD11c|p150, integrin αX, Itgax, CR4 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | Armenian Hamster |
| Clone: | N418 |
| Isotype: | IgG |
| Immunogen: | |
| Application: | FC |
Description
Description: The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).
Additional Text
Gene Name
ITGAX
Application Notes
This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.
Gene ID
16411
Uniprot ID
Q9QXH4
Antibody Clonality
Monoclonal
Storage Note
2-8°C protected from light
ATB10076 Datasheet
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