FITC Anti-Mouse CD115 (c-fms) (AFS98) Antibody

Catalogue Number: ATB10120-ABG

Manufacturer:	Abcepta
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	CSF-1-R, FMS, Colony-Stimulating Factor 1 Receptor, M-CSF Receptor, CSF1R\|Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, CSF-1-R, CSF-1R, M-CSF-R, 2.7.10.1, Proto-oncogene c-Fms, CD115, Csf1r, Csfmr, Fms
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Rat
Clone:	AFS98
Isotype:	IgG2a, kappa
Immunogen:
Application:	FC

Overview
Datasheets

Description

Description: The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor (use format appropriate for functional assays).

Additional Text

Gene Name

CSF1R

Gene ID

12978

Uniprot ID

P09581

Application Notes

This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.

Antibody Clonality

Monoclonal

Storage Note

2-8°C protected from light

ATB10120 Datasheet

Price

£166.00

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