FITC Anti-Mouse KLRG1 (2F1) Antibody
Catalogue Number: ATB10129-ABG
ATB10129 Image
ATB10129 Image
ATB10129 Image
C57Bl/6 splenocytes were stained with APC Anti-Mouse NK1.1 and 0.5 ug FITC Anti-Mouse KLRG1 (ATB10129) (right panel) or 0.5 ug FITC Golden Syrian Hamster IgG (left panel).
ATB10129 Image
C57Bl/6 splenocytes were stained with APC Anti-Mouse NK1.1 and 0.5 ug FITC Anti-Mouse KLRG1 (2F1) manufactured by Tonbo Biosciences (left panel) or eBioscience (right panel).
| Manufacturer: | Abcepta |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | CLEC15A; MAFA; MAFA-2F1; MAFA-L; MAFA-LIKE|Killer cell lectin-like receptor subfamily G member 1, Mast cell function-associated antigen 2F1, Klrg1, Mafa |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 ug |
| Host name: | Syrian Hamster |
| Clone: | 2F1 |
| Isotype: | IgG |
| Immunogen: | |
| Application: | FC |
Description
Description: The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.
Additional Text
Gene Name
KLRG1
Application Notes
This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.
Gene ID
50928
Uniprot ID
O88713
Antibody Clonality
Monoclonal
Storage Note
2-8°C protected from light
ATB10129 Datasheet
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