In Vivo Ready™ Anti-Mouse CD8a (53-6.7) Antibody

Catalogue Number: ATB10142-ABG

Manufacturer:	Abcepta
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2\|T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, Cd8a, Lyt-2, Lyt2
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	1 mg
Host name:	Rat
Clone:	53-6.7
Isotype:	IgG2a, kappa
Immunogen:
Application:	FC, IHC-P, IP, IHC-Fr, FA

Overview
Datasheets

Description

Description: The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

Additional Text

Gene Name

CD8A

Gene ID

12525

Application Notes

This purified format is guaranteed to be >90% pure as determined by SDS-PAGE analysis. Citations are provided as a convenience to you - please consult Materials and Methods sections for additional details about the use of any product in these publications.

Uniprot ID

P01731

Antibody Clonality

Monoclonal

Storage Note

2-8°C

ATB10142 Datasheet

Price

£238.00

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