In Vivo Ready™ Anti-Mouse CD28 (37.51) Antibody

Catalogue Number: ATB10145-ABG

Manufacturer:	Abcepta
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	T-cell-specific surface glycoprotein CD28, CD28, Cd28\|Tp44, T44
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	1 mg
Host name:	Syrian Hamster
Clone:	37.51
Isotype:	IgG
Immunogen:
Application:	FC, IP, FA

Overview
Datasheets

Description

Description: The 37.51 antibody reacts with mouse CD28, a 45 kDa glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of co-stimulatory receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.The 37.51 may be used as a phenotypic marker for CD28, which is expressed on all CD4+ T cells and CD8+ T cells, and on NK cells in mouse. In addition, the 37.51 antibody is widely used to activate the CD28 receptor in vitro and in vivo. Please choose the appropriate format for each application.

Additional Text

Gene Name

CD28

Gene ID

12487

Application Notes

This purified format is guaranteed to be >90% pure as determined by SDS-PAGE analysis. Citations are provided as a convenience to you - please consult Materials and Methods sections for additional details about the use of any product in these publications.

Uniprot ID

P31041

Antibody Clonality

Monoclonal

Storage Note

2-8°C

ATB10145 Datasheet

Price

£286.00

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