In Vivo Ready™ Anti-Mouse CD117 (c-Kit) (ACK2) Antibody
Catalogue Number: ATB10151-ABG
| Manufacturer: | Abcepta |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Mast/stem cell growth factor receptor Kit, SCFR, 2.7.10.1, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, CD117, Kit, Sl|Steel Factor Receptor, SCFR, cKit |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 500 ug |
| Host name: | Rat |
| Clone: | ACK2 |
| Isotype: | IgG2b, kappa |
| Immunogen: | |
| Application: | FC, ICC, IHC-P, WB, FA |
Description
Description: The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo. In addition, the antibody is reported to be cross-reactive with rat c-Kit and is extensively published for use in this species.
Additional Text
Gene Name
KIT
Gene ID
16590
Application Notes
This purified format is guaranteed to be >90% pure as determined by SDS-PAGE analysis. Citations are provided as a convenience to you - please consult Materials and Methods sections for additional details about the use of any product in these publications.
Uniprot ID
P05532
Antibody Clonality
Monoclonal
Storage Note
2-8°C
ATB10151 Datasheet
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