PE Anti-Mouse CD357 (GITR) (DTA-1) Antibody

Catalogue Number: ATB10208-ABG

Manufacturer:	Abcepta
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	TNFRSF18\|Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, CD357, Tnfrsf18, Gitr
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Rat
Clone:	DTA-1
Isotype:	IgG2b
Immunogen:
Application:	FC

Overview
Datasheets

Description

Description: The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.The DTA-1 antibody may be used for analysis of GITR expression on T cells, and is also commonly used in vitro as an agonistic antibody to induce GITR signaling in various assays (use format appropriate for functional assays).

Additional Text

Gene ID

21936

Gene Name

TNFRSF18

Application Notes

This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.

Uniprot ID

O35714

Antibody Clonality

Monoclonal

Storage Note

2-8°C protected from light

ATB10208 Datasheet

Price

£175.00

-

Quantity
Unit Size

Find out about delivery