PE-Cy7 Anti-Human CD11b (ICRF44) Antibody
Catalogue Number: ATB10239-ABG
ATB10239 Image
ATB10239 Image
ATB10239 Image
Human peripheral blood monocytes were stained with 5 uL (1 ug) PE-Cy7 Anti-Human CD11b (ATB10239) (solid line) or 1 ug PE-Cy7 Mouse IgG1 isotype control (dashed line).
ATB10239 Image
Human peripheral blood monocytes were stained with 5 uL (1 ug) PE-Cy7 Anti-Human CD11b (ICRF44) manufactured by Tonbo Biosciences (left panel) or eBioscience (right panel).
| Manufacturer: | Abcepta |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, ITGAM, CD11B, CR3A|Mac-1, integrin αM, Itgam, CR3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests |
| Host name: | Mouse |
| Clone: | ICRF44 |
| Isotype: | IgG1, kappa |
| Immunogen: | |
| Application: | FC |
Description
Description: The ICRF44 antibody reacts with human CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1, ICAM-2, ICAM-3 and ICAM-4 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The ICRF44 antibody is widely used as a marker for CD11b expression on macrophages, granulocytes, and subsets of NK cells. It is reported to be cross-reactive with a number of non-human species including Baboon, Chimpanzee, Cynomolgus, Rhesus and Swine.
Additional Text
Gene Name
ITGAM
Gene ID
3684
Uniprot ID
P11215
Application Notes
This antibody preparation has been pre-titrated and quality-tested for flow cytometry using an appropriate cell type. The antibody has been diluted for use at 5 uL per test, defined as the amount of antibody that will stain a cell sample in a final volume of approximately 100 uL. The number of cells within a sample should be determined empirically, but typically ranges between 1x10e5 to 1x10e8 cells.
Antibody Clonality
Monoclonal
Storage Note
2-8°C protected from light
ATB10239 Datasheet
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