PE-Cy7 Anti-Human CD28 (CD28.2) Antibody

Catalogue Number: ATB10245-ABG

Manufacturer:	Abcepta
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	T-cell-specific surface glycoprotein CD28, TP44, CD28, CD28\|T44, Tp44
Shipping Condition:	Blue Ice
Unit(s):	100 tests
Host name:	Mouse
Clone:	CD28.2
Isotype:	IgG1, kappa
Immunogen:
Application:	FC

Overview
Datasheets

Description

Description: The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.The CD28.2 antibody may be used as a phenotypic marker for human CD28, expressed on all CD4+ T cells and CD8+ T cells, and is widely used as a reagent for activation of the CD28 receptor in vitro and in vivo (use format suitable for functional assays). This antibody is also reported to be cross-reactive with several non-human species, including Baboon, Chimpanzee, Cynomolgus, and Rhesus.

Additional Text

Gene ID

940

Uniprot ID

P10747

Gene Name

CD28

Application Notes

This antibody preparation has been pre-titrated and quality-tested for flow cytometry using an appropriate cell type. The antibody has been diluted for use at 5 uL per test, defined as the amount of antibody that will stain a cell sample in a final volume of approximately 100 uL. The number of cells within a sample should be determined empirically, but typically ranges between 1x10e5 to 1x10e8 cells.

Antibody Clonality

Monoclonal

Storage Note

2-8°C protected from light

ATB10245 Datasheet

Price

£171.00

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