violetFluor™ 450 Anti-Mouse CD127 (IL-7Ra) (A7R34) Antibody

Catalogue Number: ATB10361-ABG

Manufacturer:	Abcepta
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217, Il17ra, Il17r\|Interleukin-7 Receptor alpha, IL-7Ra
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Rat
Clone:	A7R34
Isotype:	IgG2a, kappa
Immunogen:
Application:	FC

Overview
Datasheets

Description

Description: The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).

Additional Text

Gene Name

IL17RA

Uniprot ID

Q60943

Gene ID

16172

Application Notes

This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.

Antibody Clonality

Monoclonal

Storage Note

2-8°C protected from light

ATB10361 Datasheet

Price

£231.00

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