violetFluor™ 450 Anti-Mouse TCR beta (H57-597) Antibody

Catalogue Number: ATB10368-ABG

Manufacturer:	Abcepta
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	TCRb, TCRbeta, TCR beta\|TCRb, TCRbeta, TCR-b chain, TCR-b, b-TCR
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Armenian Hamster
Clone:	H57-597
Isotype:	IgG
Immunogen:
Application:	FC

Overview
Datasheets

Description

Description: The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.

Additional Text

Application Notes

This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.

Gene ID

21577

Antibody Clonality

Monoclonal

Storage Note

2-8°C protected from light

Gene Name

Tcrb

ATB10368 Datasheet

Price

£167.00

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