Daunorubicin HCl

Catalogue Number: B2285-APE

Manufacturer:	Apexbio
Type:	Enzyme Inhibitors
Shipping Condition:	Blue Ice
Unit(s):	10 mg, 10 mM (in 1mL DMSO), 50 mg

Overview
Datasheets

Description

Description: Daunorubicin HCl is an inhibitor of DNA topoisomerase II [1].Daunorubicin is an anthracycline antibiotic. It is also used as an effective chemotherapeutic agent against tumors especially acute myeloid leukaemia and acute lymphocytic leukaemia. Daunorubicin can affect the metabolism and synthesis of DNA and RNA. In the in vitro assay, daunorubicin inhibits the incorporation of thymidine and uridine into L1210 cells. It also inhibits the incorporation of labeled precursors into the isolated DNA and RNA from incubated cells. When treated with leukemic cells isolated from acute lymphocytic leukemia patients, daunorubicin significantly inhibits the biosynthesis of the DNA and RNA macromolecules [2, 3]. References:[1] Hande K R. Etoposide: four decades of development of a topoisomerase II inhibitor. European Journal of Cancer, 1998, 34(10): 1514-1521.[2] Momparler R L, Karon M, Siegel S E, et al. Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Cancer Research, 1976, 36(8): 2891-2895.[3] Meriwether W D, Bachur N R. Inhibition of DNA and RNA metabolism by daunorubicin and adriamycin in L1210 mouse leukemia. Cancer research, 1972, 32(6): 1137-1142.

Additional Text

Storage Note

Store at -20°C

Short Description

DNA topoisomerase II inhibitor

Solubility

≥28.2 mg/mL in DMSO; insoluble in H2O; ≥2.07 mg/mL in EtOH with gentle warming and ultrasonic

Reagent:Smile String

Cl[H].O=C(C([H])([H])[H])[C@@](C([H])([H])[C@]1([H])O[C@](C([H])([H])[C@]2([H])N([H])[H])([H])O[C@](C([H])([H])[H])([H])[C@@]2([H])O[H])(C([H])([H])C3=C1C(O[H])=C(C(C4=C5C([H])=C([H])C([H])=C4OC([H])([H])[H])=O)C(C5=O)=C3O[H])O[H]

B2285 Datasheet

B2285 CofA

B2285 MSDS

Price

£51.00

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