Bone Morphogenetic Protein 4 (BMP4, DVR4) (MaxLight 650)

Catalogue Number: B2553-20-ML650-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™650.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	Bmp2b\|Bmp2b1\|Bmp2b-1\|Bmp-4\|bone morphogenetic protein 2B\|bone morphogenetic protein 4
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	3h2.3 (3H2)
Isotype:	IgG2b
Immunogen:	Recombinant protein corresponding to mouse BMP4
Application:	ICC, WB, FLISA

Overview
Datasheets

Description

Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Bone Morphogenic Protein 4 is a polypeptide belonging to the TGF-beta superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization and uteric bud development. BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva in which it is underexpressed. In human embryonic development, BMP4 is a critical signalling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord. It acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. BMP4 stimulates differentiation of overlying ectodermal tissue. Inhibition of the BMP4 signal (by chordin, noggin or follistatin) causes the ectoderm to differentiate into the neural plate. If these cells also receive signals from FGF, they will differentiate into the spinal cord; in the absence of FGF the cells become brain tissue.

Additional Text

Gene Name

BMP4

UniProt ID

P21275

Specificity

Recognizes mouse BMP4. Recognizes human and mouse BMP4 in both reduced and non-reduced conditions. Does not crossreact with human BMP2 or human TGF-b1. Species Crossreactivity: human and rat

Gene ID

12159

Purification

Purified

Antibody Clonality

Monoclonal

B2553-20-ML650 Datasheet

Price

£1,064.00

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