Tautomycetin
Catalogue Number: B7009-APE
| Manufacturer: | Apexbio |
| Physical state: | Colourless liquid |
| Type: | Phosphatase Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
Description
Description: Tautomycetin is a potent, selective inhibitor of PP1, with IC50 values being 1.6 nM and 62 nM for the PP1 and PP2A subtypes, respectively. PP1, one of four major protein serine/threonine phosphatases (PPs), plays an important role in regulation of many cellular events such as transcription, translation, cell division, muscle contraction, glycogen synthesis, and neuronal signaling. Compared with over 40 species of natural phosphatase inhibitors reported, tautomycetin is the most specific PP1 inhibitor, which can be served as a novel powerful tool to elucidate the physiological roles of PP1 in a variety of biological events. Reference:1. Mitsuhashi S, Matsuura N, Ubukata M, et al. Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochemical and Biophysical Research Communications, 2001, 287(2): 328-331.
Additional Text
Solubility
Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Storage Note
Desiccate at -20°C
Short Description
A novel and specific protein phosphatase 1 (PP1) inhibitor
Reagent:Smile String
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B7009 CofA
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