Sodium molybdate
Catalogue Number: B7843-APE
| Manufacturer: | Apexbio |
| Physical state: | A solid |
| Type: | Phosphatase Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10000 mg, 5000 mg |
Description
Description: Sodium molybdate is an acid phosphatase inhibitor. The osteoclastic acid phosphatase isoenzyme, secreted by osteoclasts, is a member of a widely-distributed class of iron-containing proteins with acid phosphatase activity. Elevated plasma isoenzyme levels are associated with increased bone turnover in metabolic disease. By inhibiting this class of acid phosphatases, sodium molybdate is capable of abolishing bone resorption. In addition, sodium molybdate has been shown to stabilize the nonactivated glucocorticoid-receptor complex. References:1. Zaidi M, Moonga B, Moss DW, et al. Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochemical and Biophysical Research Communications, 1989, 159(1): 68-71.2. Denis M, Wikstroem AC, Gustafsson JA. The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein. Journal of Biological Chemistry, 1987, 262(24): 11803-11806.
Additional Text
Storage Note
Store at -20°C
Reagent:Smile String
[O-][Mo](=O)([O-])=O.[Na+].[Na+]
Solubility
insoluble in EtOH; insoluble in DMSO; ≥20.6 mg/mL in H2O
Short Description
An acid phosphatase inhibitor
B7843 CofA
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