ddhCTP

Catalogue Number: B8293-APE

Manufacturer:Apexbio
Molecular Weight:465.14
Molecular Formula:C9H14N3O13P3
Type:Biochemicals
Alias:3'-deoxy-3',4'-didehydro-CTP
Shipping Condition:Blue Ice
Unit(s): 25 mg, 5 mg

Description

Description: Viperin, a member of the radical S-adenosyl-l-methionine (SAM) superfamily of enzymes, is an interferon-inducible protein implicated in the inhibition of replication of a broad range of RNA and DNA viruses, including dengue virus, West Nile virus, hepatitis C virus, influenza A virus, rabies virus and HIV. Viperin catalyses the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP), a previously undescribed biologically relevant molecule, via a SAMdependent radical mechanism [1].ddhCTP, can be produced in mammalian cytosol, is a chain terminator for the RNA-dependent RNA polymerases from multiple members of the Flavivirus genus, and directly inhibits replication of Zika virus in vivo[1]. Reference:[1] Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo. A naturally occurring antiviral ribonucleotide encoded by the human genome. Nature, 2018; DOI: 10.1038/s41586-018-0238-4.

Additional Text

Reagent:Smile String

OC1C=C(COP(OP(OP(O)(O)=O)(O)=O)(O)=O)OC1N2C(N=C(N)C=C2)=O

Short Description

Chain terminator for the RNA-dependent RNA polymerases

Price
2343.00


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