Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)]
Catalogue Number: BAB0162-BB-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | CD340; Metastatic lymph node gene 19 protein (MLN 19); Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; p185HER2; EGFR |
| Shipping Condition: | Blue Ice |
| Unit(s): | 5 mg |
| Host name: | Mouse |
| Clone: | 4D5-8 (trastuzumab) |
| Isotype: | IgG2a |
| Immunogen: | A431 cells (human epidermoid carcinoma) (over)expressing EGFR. |
| Application: | ELISA, FC, IHC |
Additional Text
Gene ID
2064
Gene Name
ERBB2
Uniprot ID
P04626
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).
Short Description
This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against human HER2 (Fab) and one arm directed against mouse CD3e (scFv).
BAB0162-BB Datasheet
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