Anti-EGFRvIII [L8A4]
Catalogue Number: BAB0164-BB-ABA
| Manufacturer: | Vector Laboratories, Inc (ABA) |
| Type: | Recombinant Monoclonal |
| Alias: | Epidermal Growth Factor Receptor variant III |
| Shipping Condition: | Blue Ice |
| Unit(s): | 5 mg |
| Host name: | Mouse |
| Clone: | L8A4 |
| Isotype: | IgG2a |
| Immunogen: | Pep 3-KLH (Pep 3 is a 14-amino acid peptide corresponding to the predicted amino acid sequence at the fusion junction and KLH stands for keyhole limpet hemocyanin) at da 40 and 103, HC2 20 d2 cells at day 1, 25, 74, 87. And fusion with the nonimmunoglobulin-secreting Kearney variant of P3X63/Ag8.653. |
| Application: | ELISA, FC, IF, WB, IHC, SPR |
Additional Text
Gene ID
1956
Gene Name
EGFR
Uniprot ID
P00533
Purification
Purified
Antibody Clonality
Recombinant Monoclonal
Storage Note
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Application Notes
This antibody can be used to detect EGFRvIII, a mutated EGFR variant, in immunohistochemical staining, Western Blot, ELISA and flow-cytometry. Chou et al (2016, PMID: 27825958) used this antibody to detect EGFRvIII in acetone and PFA fixed sections by fluorescent immunohistochemistry.
Short Description
This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against human EGFRvIII (Fab) and one arm directed against mouse CD3e (scFv).
BAB0164-BB Datasheet
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