MMP-13 Polyclonal Antibody
Catalogue Number: BS-0575R-BSS
bs-0575R Image
bs-0575R Image
bs-0575R Image
bs-0575R Image
bs-0575R Image
bs-0575R Image
Formalin-fixed and paraffin embedded rat articular cartilage labeled with Anti-MMP-13 Polyclonal Antibody (bs-0575R), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining
bs-0575R Image
Generously provided by Markus Linder from Medical University Vienna as part of the Bioss Discovery Program. Formalin-fixed, paraffin embedded, and decalcified in EDTA mouse bone labeled with Anti-MMP-13 Polyclonal Antibody, Unconjugated (bs-0575R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
bs-0575R Image
Formalin-fixed and paraffin embedded human bladder cancer labeled with Rabbit Anti-MMP-13 Polyclonal Antibody, Unconjugated (bs-0575R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
bs-0575R Image
Human PC3 lysates probed with Rabbit Anti-MMP13 Polyclonal Antibody, Unconjugated (bs-0575R) at 1:300 overnight at 4°C. Followed by a conjugated secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at 37°C.
bs-0575R Image
Human U2os lysates probed with Rabbit Anti-MMP13 Polyclonal Antibody, Unconjugated (bs-0575R) at 1:300 overnight at 4°C. Followed by a conjugated secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at 37°C.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | CLG3; MANDP1; MMP-13; Collagenase 3; Matrix metalloproteinase-13; MMP13 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human MMP13 |
| Application: | ELISA, IHC-P, WB, IHC-Fr |
Description
Description: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
Additional Text
Gene ID
4322
Gene Name
MMP13
Uniprot ID
P45452
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-0575R Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations