Catalogue Number: BS-0679R-CY5.5-BSS
Manufacturer: | Bioss Inc |
Type: | Polyclonal Primary Antibody - Conjugated |
Alias: | DER3; HRD1; E3 ubiquitin-protein ligase synoviolin; Synovial apoptosis inhibitor 1; SYVN1; KIAA181 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 ul |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | KLH conjugated synthetic peptide derived from human SYVN1 |
Application: | FC, ICC, IF, IHC-P, WB, IHC-Fr |
Description: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
SYVN1
Q86TM6
84447
Protein A purified
1 ug/ul
Polyclonal
Unmodified
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.