Acetyl p53(K382) Polyclonal Antibody

Catalogue Number: BS-0905R-BSS

Manufacturer:Bioss Inc
Shelf Life:12 months
Type:Polyclonal Primary Antibody - Unconjugated
Alias:P53; BCC7; LFS1; TRP53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53
Shipping Condition:Blue Ice
Unit(s): 100 ul, 20 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: KLH conjugated synthetic acetylpeptide derived from human p53 around acetylation site of K382
Application: ELISA, FC, ICC, IF, IHC-P, WB, IHC-Fr

Description

Description: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Additional Text

Gene Name

TP53

Gene ID

7157

Uniprot ID

P04637

Purification

Protein A purified

Concentration

1 ug/ul

Antibody Clonality

Polyclonal

Modification

Acetylated, Lys382

Storage Note

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.