MCKD2 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated

Catalogue Number: BS-0916R-A594-BSS

Manufacturer:Bioss Inc
Shelf Life:12 months
Preservative:0.09% sodium azide
Type:Polyclonal Primary Antibody - Conjugated
Alias:THP; Urehd1; urehr4; Uromodulin; Tamm-Horsfall urinary glycoprotein; Umod
Shipping Condition:Blue Ice
Storage Condition:4°C
Unit(s): 100 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: KLH conjugated synthetic peptide derived from mouse MCKD2

Description

Description: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial (By similarity). Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.

Additional Text

Concentration

1ug/ul

Applications with dilutions

IF(IHC-P)(1:50-200)

Excitation/ Emission Wavelengths

590nm/617nm

Modification

Unmodified

Synonym

THP; Urehd1; urehr4; Uromodulin; Tamm-Horsfall urinary glycoprotein; Umod