DOK6 Polyclonal Antibody, PE-Cy5.5 Conjugated
Catalogue Number: BS-11066R-PE-CY5.5-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Alias: | Docking protein 5; Docking protein 5 like; Docking protein 6; DOK 6; DOK6; DOK-6; DOK5; DOK 5; DOK-5; DOK5L; Downstream of tyrosine kinase 6; HsT3226; MGC20785; Protein dok 5; DOK6_HUMAN. |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human DOK6 |
| Application: | WB |
Description
Description: The downstream of kinase family (Dok-1-7) are members of a class of docking? proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
Additional Text
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Excitation
488nm/694nm
BS-11066R-PE-CY5.5 Datasheet
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