MYRF/C11orf9 Polyclonal Antibody
Catalogue Number: BS-11191R-BSS
bs-11191R Image
bs-11191R Image
bs-11191R Image
bs-11191R Image
Lane 1: Human A549 cell lysates; Lane 2: Human HepG2 cell lysates; Lane 3: Human U2OS cell; Lane 4: Human A431 cell lysates; lysates probed with MRF/C11orf9 Polyclonal Antibody, Unconjugated (bs-11191R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
bs-11191R Image
Formalin-fixed and paraffin embedded rat brain labeled with Anti-MRF/C11orf9 Polyclonal Antibody, Unconjugated (bs-11191R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
bs-11191R Image
Mouse brain lysate probed with Rabbit Anti-MRF/C11orf9 Polyclonal Antibody, Unconjugated (bs-11191R) at 1:200 overnight at 4°C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 for 90 min at 37°C. Predicted band 124kD. Observed band size: 124kD
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | MRF; Ndt80; pqn-47; C11orf9; Myelin regulatory factor; Myelin gene regulatory factor; MYRF; KIAA0954 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human MYRF |
| Application: | ELISA, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).
Additional Text
Uniprot ID
Q9Y2G1
Gene ID
745
Purification
Protein A purified
Concentration
1 ug/ul
Gene Name
MYRF
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-11191R Datasheet
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