ROCK1 Polyclonal Antibody
Catalogue Number: BS-1166R-BSS
bs-1166R Image
bs-1166R Image
bs-1166R Image
bs-1166R Image
bs-1166R Image
bs-1166R Image
Mouse brain lysates probed with ROCK1 Polyclonal Antibody, Unconjugated (bs-1166R) at 1:500 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37°C.
bs-1166R Image
Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti-ROCK1 Polyclonal Antibody, Unconjugated (bs-1166R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
bs-1166R Image
Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-ROCK1 Polyclonal Antibody, Unconjugated (bs-1166R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
bs-1166R Image
Formalin-fixed and paraffin embedded rat heart labeled with Anti-ROCK1 Polyclonal Antibody, Unconjugated (bs-1166R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
bs-1166R Image
Lane 1: Mouse Cerebrum lysates; Lane 2: Rat Cerebrum lysates probed with ROCK1 Polyclonal Antibody, Unconjugated (bs-1166R) at 1:300 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | ROCK-I; P16ROCK; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; p16 ROCK-1; ROCK1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human ROCK1 |
| Application: | ELISA, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
Additional Text
Gene Name
ROCK1
Gene ID
6093
Uniprot ID
Q13464
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-1166R Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations