ELAVL2 + ELAVL4 Polyclonal Antibody, Cy3 Conjugated
Catalogue Number: BS-11743R-CY3-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Alias: | ELAV like protein; ELAVL4; hCG_2031550; A0A0R4J2E6_HUMAN; ELAVL2; A0A0A0MRX1_HUMAN |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human ELAVL2 |
| Application: | ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites.
Additional Text
Purification
Protein A purified
Gene ID
1993; 1996
Concentration
1 ug/ul
Gene Name
ELAVL2, ELAVL4
Antibody Clonality
Polyclonal
Modification
Unmodified
Uniprot ID
A0A0A0MRX1, A0A0R4J2E6
Storage Note
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Excitation
512,550nm/570,615nm
bs-11743R-Cy3 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations