Integrin Alpha V + Beta 3 Polyclonal Antibody
Catalogue Number: BS-1310R-BSS
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Human U937 probed with Integrin Alpha V + Beta 3 Antibody, Unconjugated (bs-1310R ) at 0.2ug for 30 minutes followed by incubation with a PE Conjugated secondary (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange).
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HUVEC cell lysates probed with Integrin Alpha V + Beta 3 (CD51+CD61) Polyclonal Antibody, Unconjugated (bs-1310R) at 1:300 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37°C.
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MCF-7 cells probed with Rabbit Anti-Integrin Alpha V + Beta 3 (CD51+CD61) Polyclonal Antibody (bs-1310R) at 1:100 for 60 minutes at room temperature followed by Goat Anti-Rabbit IgG (H+L) Alexa Fluor 488 Conjugated Secondary Antibody.
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Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti Integrin Alpha V + Beta 3 (CD51+CD61)Polyclonal Antibody, Unconjugated (bs-1310R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | CD51; MSK8; VNRA; VTNR; Integrin alpha-V; Vitronectin receptor subunit alpha; ITGAV; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16; Integrin beta-3; Platelet membrane glycoprotein IIIa; ITGB3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 3 |
| Application: | ELISA, FC, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Additional Text
Purification
Protein A purified
Uniprot ID
P05106, P06756
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Gene ID
3685; 3690
Gene Name
ITGAV, ITGB3
Modification
Unmodified
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-1310R Datasheet
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