Frizzled 10/CD350 Polyclonal Antibody
Catalogue Number: BS-13216R-BSS
BS-13216R Image
BS-13216R Image
BS-13216R Image
Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-Frizzled 10/CD350 Polyclonal Antibody, Unconjugated (bs-13216R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
BS-13216R Image
L1 mouse embryo lysate L2 human colon carcinoma lysates probed with Rabbit Anti-Frizzled 10/CD350 Polyclonal Antibody, Unconjugated (bs-13216R) at 1:200 overnight at 4°C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 for 90 min at RT.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Fz10; FzE7; CD350; FZ-10; hFz10; Frizzled-10; FZD10 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human Frizzled 10/CD350 |
| Application: | ELISA, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Additional Text
Gene Name
FZD10
Gene ID
11211
Uniprot ID
Q9ULW2
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
bs-13216R Datasheet
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