phospho-LRP5 (Thr1492) Polyclonal Antibody, PerCP-Cy5.5 Conjugated
Catalogue Number: BS-25114R-PERCP-CY5.5-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated Synthesised phosphopeptide derived from human LRP5 around the phosphorylation site of Thr1492 |
| Application: | IF |
Description
Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Additional Text
Gene Name
LRP5
Uniprot ID
O75197
Gene ID
4041
Purification
Protein A purified
Antibody Clonality
Polyclonal
Modification
Unmodified
Concentration
1 mg/ml
Storage Note
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Excitation
482nm/694nm
BS-25114R-PERCP-CY5.5 Datasheet
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