BLNK(Tyr96) Polyclonal Antibody

Catalogue Number: BS-3054R-BSS

Manufacturer:	Bioss Inc
Shelf Life:	12 months
Type:	Polyclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 20 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	KLH conjugated synthetic phosphopeptide derived from human BLNK around the phosphorylation site of Tyr96 [DS(p-Y)EP]
Application:	ELISA, ICC, IF, IHC-P, WB, IHC-Fr

Overview
Datasheets

Description

Description: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

Additional Text

Gene ID

29760

Gene Name

BLNK

Uniprot ID

Q8WV28

Modification

Phosphorylated, Tyr96

Purification

Protein A purified

Concentration

1 ug/ul

Antibody Clonality

Polyclonal

Specificity

bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; BLNK

Storage Note

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

bs-3054R Datasheet

Price

£313.00

-

Quantity
Unit Size

Find out about delivery