Phospho-Gab1 (Tyr627) Polyclonal Antibody, AbBy Fluor-555 Conjugated
Catalogue Number: BS-3165R-BF555-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Alias: | GAB1 (phospho Y627); Gab1(Phospho-Tyr627); p-Gab1 (Tyr627); GAB1_HUMAN; GRB2-associated-binding protein 1; GAB1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated Synthesised phosphopeptide derived from human Gab1 around the phosphorylation site of Tyr627 |
| Application: | WB |
Description
Description: Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.
Additional Text
Gene ID
2549
Gene Name
GAB1
Uniprot ID
Q13480
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Phosphorylated, Tyr627
Storage Note
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Excitation
553nm/568nm
BS-3165R-BF555 Datasheet
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