Merlin (Ser518) Antibody

Catalogue Number: BS-3291R-BSS

Manufacturer:Bioss Inc
Shelf Life:12 months
Type:Polyclonal Primary Antibody - Unconjugated
Alias:ACN; SCH; BANF; Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin; NF2
Shipping Condition:Blue Ice
Unit(s): 100 ul, 20 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: KLH conjugated synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Ser518
Application: ELISA, ICC, IF, IHC-P, WB, IHC-Fr

Description

Description: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Additional Text

Gene ID

4771

Gene Name

NF2

Uniprot ID

P35240

Modification

Phosphorylated, Ser518

Purification

Protein A purified

Concentration

1 ug/ul

Antibody Clonality

Polyclonal

Storage Note

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.