ATG1(Ser556) Polyclonal Antibody, Biotin Conjugated
Catalogue Number: BS-3464R-BIOTIN-BSS
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Conjugated |
| Alias: | ATG1; ATG1A; UNC51; hATG1; Unc51.1; Serine/threonine-protein kinase ULK1; Autophagy-related protein 1 homolog; Unc-51-like kinase 1; ULK1; KIAA0722 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic phosphopeptide derived from human ATG1 around the phosphorylation site of Ser556 |
| Application: | ELISA, IHC-P, WB, IHC-Fr |
Description
Description: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Additional Text
Uniprot ID
O75385
Gene Name
ULK1
Gene ID
8408
Purification
Protein A purified
Modification
Phosphorylated, Ser556
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Storage Note
Store at -20°C for 12 months.
bs-3464R-Biotin Datasheet
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