Recombinant human MARCH8 protein, APC Conjugated
Catalogue Number: BS-42425P-APC-BSS
| Manufacturer: | Bioss Inc |
| Physical state: | Aqueous |
| Type: | Protein - Conjugated |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 500 ug |
Description
Description: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. MARCH8 (membrane-associated ring finger (C3HC4) 8), also known as MIR or RNF178 (RING finger protein 178), is a 291 amino acid multi-pass membrane protein that localizes to vesicle membranes and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, including immature dendritic cells, MARCH8 functions as an E3 ubiquitin ligase that is thought to regulate immune responses by promoting the ubiquitination and subsequent degradation of target proteins, such as B7-2 and CD71.
Additional Text
Gene ID
220972
Uniprot ID
Q5T0T0
Protein Tag
GST Tag, HIS Tag
Gene Name
MARCHF8
Storage Note
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Endotoxin
Not Tested
Short Description
Recombinant human MARCH8 protein in E.coli with N-GST&C-His. It contains the amino acid sequence of 1-154/291
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