Recombinant human PD-1 Protein, C-His (HEK293)
Catalogue Number: BS-43013P-BSS
| Manufacturer: | Bioss Inc |
| Type: | Immune Checkpoint Proteins |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Blue Ice |
| Storage Condition: | -70°C |
| Unit(s): | 100 ug, 500 ug |
| Application: | ELISA |
Description
Description: This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. CD279 is an immunoglobulin superfamily member, also known as Programmed Cell Death 1. Programmed Cell Death 1 is expressed on a subset of CD4-CD8 thymocytes, and on activated T and B cells. Programmed Cell Death 1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The Programmed Cell Death 1 ligands, PDL1 (also known as B7H1) and PDL2 (B7DC), are members of the B7 immunoglobulin superfamily.
Additional Text
Gene Name
PDCD1
Gene ID
5133
Uniprot ID
Q15116
Protein Tag
HIS Tag
Storage Note
The product should be stored at -70°C or -20°C.
Short Description
Recombinant human PD-1 Protein, C-His (HEK293) protein is expressed in HEK293 with C-His. It contains the amino acid sequence of 24-170/288.
Endotoxin
Not Tested
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