Nucleophosmin Polyclonal Antibody
Catalogue Number: BS-4757R-BSS
bs-4757R Image
bs-4757R Image
bs-4757R Image
BS-4757R Image
bs-4757R Image
Formalin-fixed and paraffin embedded human kidney labeled with Anti-Nucleophosmin Polyclonal Antibody, Unconjugated (bs-4757R) at 1:300 followed by conjugation to the secondary antibody and DAB staining.
bs-4757R Image
Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-Nucleophosmin Polyclonal Antibody, Unconjugated (bs-4757R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
bs-4757R Image
L1 rat kidney lysate L2 rat brain lysates probed with Anti Nucleophosmin Polyclonal Antibody, Unconjugated (bs-4757R) at 1:200 overnight at 4°C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 for 90 min at 37°C. Predicted band 33kD. Observed band size: 33kD
BS-4757R Image
Lane 1: Mouse NIH/3T3 cell lysates; Lane 2: Human K562 cell lysates; Lane 3: Human HepG2 cell lysates; Lane 4: Human HeLa cell lysates; Lane 5: Human SH-SY5Y cell lysates probed with Nucleophosmin Polyclonal Antibody, Unconjugated (bs-4757R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | B23; NPM; Nucleophosmin; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin; NPM1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human Nucleophosmin |
| Application: | ELISA, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
Additional Text
Gene Name
NPM1
Uniprot ID
P06748
Gene ID
4869
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-4757R Datasheet
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