Recombinant human EPO protein (Active, HEK293), APC Conjugated

Catalogue Number: BS-48036P-APC-BSS

Manufacturer:	Bioss Inc
Physical state:	Aqueous
Type:	Protein - Conjugated
Host Cell:	HEK293 cells
Shipping Condition:	Blue Ice
Unit(s):	10 ug, 50 ug

Overview

Description

Description: Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. It is produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. Genetic variation in erythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. It has a longer circulating half-life in vivo. Erythropoietin is being much misused as a performance-enhancing drug in endurance athletes.

Additional Text

Gene Name

EPO

Gene ID

2056

Uniprot ID

P01588

Protein Tag

Untagged

Storage Note

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Endotoxin

Less than 0.5EU per ug by the LAL method.

Short Description

Recombinant human EPO protein is expressed in HEK293

Price

£273.00

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