CXCR7/RDC1 Polyclonal Antibody
Catalogue Number: BS-4897R-BSS
bs-4897R Image
bs-4897R Image
bs-4897R Image
Formalin-fixed and paraffin embedded rat brain labeled with Anti-CXCR7/RDC1 Polyclonal Antibody, Unconjugated (bs-4897R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
bs-4897R Image
Formalin-fixed and paraffin embedded rat kidney labeled with Anti-CXCR7/RDC1 Polyclonal Antibody, Unconjugated (bs-4897R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159; Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; ACKR3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human CXCR7/RDC1 |
| Application: | ELISA, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
Additional Text
Gene ID
57007
Uniprot ID
P25106
Gene Name
ACKR3
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-4897R Datasheet
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