phospho-CASC3 (Tyr181) Polyclonal Antibody, PerCP Conjugated

Catalogue Number: BS-5283R-PERCP-BSS

Manufacturer:	Bioss Inc
Type:	Polyclonal Primary Antibody - Conjugated
Alias:	Barentsz protein; Btz; Cancer susceptibility candidate gene 3 protein; Metastatic lymph node protein 51; MLN 51 protein; MLN51; Protein barentsz; Protein CASC3; Protein MLN 51; CASC3_HUMAN.
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	KLH conjugated synthetic phosphopeptide derived from human CASC3 around the phosphorylation site of Tyr181
Application:	ICC, IF, IHC-P, WB, IHC-Fr

Overview
Datasheets

Description

Description: The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exonexon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex serves as a key modulator of spliced mRNA metabolism. MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer. The function of MLN51 in mammals remains elusive. Its fly homolog, named barentsz, as well as the proteins mago nashi and tsunagi have been shown to be required for proper oskar mRNA localization to the posterior pole of the oocyte. Magoh and Y14, the human homologs of mago nashi and tsunagi, are core components of the exon junction complex (EJC). The EJC is assembled on spliced mRNAs and plays important roles in post-splicing events including mRNA export, nonsense-mediated mRNA decay, and translation. Human MLN51 is an RNA-binding protein present in ribonucleo-protein complexes.

Additional Text

Gene Name

CASC3

Gene ID

22794

Purification

Protein A purified

Concentration

1 ug/ul

Antibody Clonality

Polyclonal

Modification

Phosphorylated, Tyr181

Storage Note

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Excitation

482nm/677nm

BS-5283R-PERCP Datasheet

Price

£398.00

-

Quantity
Unit Size

Find out about delivery