RNF56 Polyclonal Antibody, Cy3 Conjugated

Catalogue Number: BS-5949R-CY3-BSS

Manufacturer:Bioss Inc
Shelf Life:12 months
Preservative:0.09% Sodium azide
Physical state:Lyophilized
Type:Polyclonal Primary Antibody - Conjugated
Alias:Cbl-b; RNF56; Nbla00127; E3 ubiquitin-protein ligase CBL-B; Casitas B-lineage lymphoma proto-oncogene b; RING finger protein 56; SH3-binding protein CBL-B; Signal transduction protein CBL-B; CBLB
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: KLH conjugated synthetic peptide derived from human RNF56/CBL-B

Description

Description: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

Additional Text

Attention

To ensure the best quality, Bioss primary antibodies are conjugated upon ordering. Please allow 2 weeks for this process.

Concentration

1ug/ul

Applications with dilutions

IF(IHC-P)(1:50-200)

Excitation/ Emission Wavelengths

512,550nm/570,615nm

Free Samples:

New From Bioss Free Antibody Samples

Modification

Unmodified

Synonym

Cbl-b; RNF56; Nbla00127; E3 ubiquitin-protein ligase CBL-B; Casitas B-lineage lymphoma proto-oncogene b; RING finger protein 56; SH3-binding protein CBL-B; Signal transduction protein CBL-B; CBLB