AF4 Polyclonal Antibody, Cy3 Conjugated

Catalogue Number: BS-5958R-CY3-BSS

Manufacturer:Bioss Inc
Shelf Life:12 months
Preservative:0.09% sodium azide
Physical state:Lyophilized
Type:Polyclonal Primary Antibody - Conjugated
Shipping Condition:Blue Ice
Storage Condition:4°C
Unit(s): 100 ul
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: KLH conjugated synthetic peptide derived from human AF 4 protein

Description

Description: Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.

Additional Text

Attention

To ensure the best quality, Bioss primary antibodies are conjugated upon ordering. Please allow 2 weeks for this process.

Concentration

1ug/ul

Applications with dilutions

IF(IHC-P)(1:50-200)

Excitation/ Emission Wavelengths

512,550nm/570,615nm

Free Samples:

New From Bioss Free Antibody Samples

Modification

Unmodified

Synonym

AF 4; AF 4 protein; AF-4 protein; AF4/FMR2 family member 1; AFF 1; AFF1; AFF1_HUMAN; ALL1 fused gene from chromosome 4; ALL1-fused gene from chromosome 4 protein; FEL; MLLT2; MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2; Protein AF-4; Protein FEL; Proto-oncogene AF4.