Collagen 1, alpha 1 propeptide Antibody
Catalogue Number: BS-70045R-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide corresponding to amino acid residues specific to the human collagen 1, alpha 1 propeptide conjugated to keyhole limpet hemocyanin (KLH). |
| Application: | IHC-P, WB, IHC |
Description
Description: Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005)
Additional Text
Gene Name
COL1A1
Uniprot ID
P02452
Gene ID
1277
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Modification
Unmodified
Specificity
Alpha 1 type I collagen antibody, Alpha 2 type I collagen antibody, alpha 2 type I procollagen antibody, alpha 2(I) procollagen antibody, alpha 2(I)-collagen antibody, Alpha-1 type I collagen antibody, alpha1(I) procollagen antibody, CO1A1_HUMAN antibody, COL1A1 antibody, COL1A2 antibody, collagen alpha 1 chain type I antibody, Collagen alpha-1(I) chain antibody, collagen alpha-1(I) chain preproprotein antibody, Collagen I alpha 1 polypeptide antibody, Collagen I alpha 2 polypeptide antibody, collagen of skin tendon and bone, alpha-1 chain antibody, collagen of skin tendon and bone alpha-2 chain antibody, Collagen type I alpha 1 antibody, Collagen type I alpha 2 antibody, EDSC antibody, OI1 antibody, OI2 antibody, OI3 antibody, OI4 antibody, pro-alpha-1 collagen type 1 antibody, type I proalpha 1 antibody, type I procollagen alpha 1 chain antibody, Type I procollagen antibody
Storage Note
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
BS-70045R Datasheet
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