GluR1-Subunit (Ser845) Antibody
Catalogue Number: BS-70122R-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 150 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser845 of rat GluR1, conjugated to keyhole limpet hemocyanin (KLH). |
| Application: | IHC-P, WB, IHC |
Description
Description: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinaenen et al., 1990; Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. Phosphorylation of Ser-845 on GluR1 is thought to be mediated by PKA and phosphorylation of this site increases the conductance of the AMPAR (Roche et al., 1996; Banke et al., 2000). In addition, phosphorylation of this site has been linked to synaptic plasticity as well as learning and memory (Lee at al., 2003; Esteban at al., 2003).
Additional Text
Gene Name
GRIA1
Uniprot ID
P19490
Gene ID
50592
Modification
Phosphorylated, Ser845
Antibody Clonality
Polyclonal
Storage Note
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
GLUR 1 antibody, GLUR A antibody, AMPA 1 antibody, AMPA selective glutamate receptor 1 antibody, AMPA-selective glutamate receptor 1 antibody, GluA1 antibody, GLUH1 antibody, GluR K1 antibody, GluR-1 antibody, GluR-A antibody, GluR-K1 antibody, GLUR1 antibody, GLURA antibody, GluRK1 antibody, Glutamate receptor 1 antibody, Glutamate receptor ionotropic AMPA 1 antibody, Glutamate receptor ionotropic antibody, Glutamate receptor, ionotropic, AMPA 1 antibody, Gria1 antibody, GRIA1_HUMAN antibody, HBGR1 antibody, MGC133252 antibody, OTTHUMP00000160643 antibody, OTTHUMP00000165781 antibody, THUMP00000224241 antibody, OTTHUMP00000224242 antibody, OTTHUMP00000224243 antibody
Purification
Antigen Affinity purification from Pooled whole antiserum
BS-70122R Datasheet
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