NSE (Neuron specific enolase) Antibody
Catalogue Number: BS-70203R-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant human NSE expressed in and purified from E. coli. |
| Application: | IHC-P, WB, IHC |
Description
Description: Neuron specific enolase (NSE) is an enzyme which catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway, and also the reverse reaction in gluconeogenesis. It is one of three mammalian enolases, which are also known as ENO1, ENO2, and ENO3 or alternately as enolase alpha, beta and gamma. The three enolases have different cell type specific expression patterns, so that antibodies to them are useful cell type specific markers.(MacAlesse et al., 1988). NSE corresponds to ENO2 or enolase gamma and is heavily expressed in neuronal cells. ENO1 is also known as enolase alpha and as non-neuronal enolase. The third enolase, ENO3 or enolase beta, is expressed in muscle cells. Since neurons require a great deal of energy, they are very rich in glycolytic enzymes such a GAPDH and NSE. Antibodies to this protein are therefore useful to identify neuronal cell bodies, developing neuronal lineage and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood has also been used as a biomarker of neuronal injury (2).
Additional Text
Gene Name
ENO2
Gene ID
2026
Uniprot ID
P09104
Antibody Clonality
Polyclonal
Modification
Unmodified
Specificity
2 phospho D glycerate hydrolyase antibody, 2-phospho-D-glycerate hydro-lyase antibody, Eno 2 antibody, ENO2 antibody, ENOG antibody, ENOG_HUMAN antibody, Enolase 2 (gamma, neuronal) antibody, Enolase 2 antibody, Enolase 2 gamma neuronal antibody, Enolase2 antibody, Epididymis secretory protein Li 279 antibody, Gamma enolase antibody, Gamma-enolase antibody, HEL S 279 antibody, Neural enolase antibody, Neuron specific enolase antibody, Neuron specific gamma enolase antibody, Neuron-specific enolase antibody, neuronal enriched enolase antibody, Neurone specific enolase antibody, NSE antibody
Storage Note
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Purification
Neat whole antiserum
BS-70203R Datasheet
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