Pre-Pro-Vasopressin
Catalogue Number: BS-70308R-BSS
| Manufacturer: | Bioss Inc |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | ADH antibody, Antidiuretic hormone antibody, Arginine vasopressin neurophysin II antibody, ARVP antibody, AVP antibody, AVP NPII antibody, copeptin antibody, Vasopressin neurophysin II copeptin antibody, VP antibody |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide corresponding to key amino acid residues surrounding the cleavage sites for the human vasopressin precursor peptide, conjugated to keyhole limpet hemocyanin (KLH). |
| Application: | IHC-P, WB, IHC |
Description
Description: Vasopressin is a nine amino-acid peptide hormone that plays a key role in water and blood pressure homeostasis (Qureshi S., et al 2014). Vasopressin is the end-product of a highly processed 164 amino acid pre-pro-peptide. Processing of the vasopressin pre-pro-peptide results in three distinct peptides with a 1:1:1 ratio: vasopressin, neurophysin II, and copeptin (Arroyo J.P. et al, 2021). Vasopressin is the biologically active hormone, neurophysin II is a carrier molecule for vasopressin, and copeptin is the c-terminal glycosylated end-product. Vasopressin has been thought to be primarily made in the brain, and the sole source of vasopressin stimulating vasopressin V2 receptors in the kidney until recent studies (Arroyo JP, et al 2022). This antibody specially detects uncleaved pre-pro-vasopressin, accurately identifying locally produced vasopressin versus peripheral uptake of hypothalamic vasopressin or related peptides (Arroyo J.P. et al, 2022). This key research tool aided the Arroyo group in discovering immunoreactive vasopressin outside of the brain by recognizing localized vasopressin in human and mouse kidney, specifically in the distal nephron.
Additional Text
Gene Name
AVP
Uniprot ID
P01185
Gene ID
551
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Purification
Antigen Affinity purification from Pooled whole antiserum
BS-70308R Datasheet
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