nNOS (C-terminal region) Antibody

Catalogue Number: BS-70578R-BSS

Manufacturer:	Bioss Inc
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	nNOS, Constitutive NOSb, neuronal nitric oxide synthase, NCNOS
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Amino acid residues within the C-terminal region of human nNOS. This human nNOS sequence has high homology with similar regions in rat and mouse nNOS.
Application:	IHC-P, WB, IHC

Overview
Datasheets

Description

Description: Nitric oxide (NO) has a broad range of biological activities and is implicated in signaling pathways in phylogenetically diverse species. Nitric oxide synthases (NOS), the enzymes responsible for synthesis of NO, are homodimers whose monomers are themselves two fused enzymes: a cytochrome reductase and a cytochrome that requires three cosubstrates (L-arginine, NADPH, and oxygen) and five cofactors or prosthetic groups (FAD, FMN, calmodulin, tetrahydrobiopterin, and heme). Several distinct NOS isoforms are produced from three distinct genes. These include two constitutive Ca2+/CaM-dependent forms of NOS: nNOS (also designated bNOS, NOS-I), whose activity was first identified in neurons and eNOS (also designated ecNOS, NOS-III) first identified in endothelial cells. The inducible form of NOS, iNOS (also designated NOS-II), is Ca2+ independent and is expressed in a broad range of cell types. This form of NOS is induced after stimulation with cytokines and exposure to microbial products.

Additional Text

Gene Name

NOS1

Gene ID

4842

Uniprot ID

P29475

Purification

Affinity Purified

Antibody Clonality

Polyclonal

Modification

Unmodified

Storage Note

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

BS-70578R Datasheet

Price

£333.00

-

Quantity
Unit Size

Find out about delivery