SIRT4 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated

Catalogue Number: BS-7537R-A594-BSS

Manufacturer:Bioss Inc
Shelf Life:12 months
Preservative:0.09% Sodium azide
Type:Polyclonal Primary Antibody - Conjugated
Alias:SIR2L4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent ADP-ribosyltransferase sirtuin-4; Regulatory protein SIR2 homolog 4; SIR2-like protein 4; SIRT4
Shipping Condition:Blue Ice
Storage Condition:2-8°C
Unit(s): 100 ul
Host name: Rabbit
Isotype: IgG
Immunogen: KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4
Application: IF, IHC-P, IHC-Fr


Description: Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.

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1 ug/ul